what is sterilizing immunity

Found inside – Page 263... during the year since infection . The resistance of rabbits to Mycobacterium tuberculosis is primarily one of nonreception of the animal tissue to the microorganism . It is not a sterilizing immunity , since the organism may remain viable in the ... Found inside – Page 214Chapter 6 introduced the topic of vaccination but dealt only with vaccines that conferred a completely sterilizing immunity on vaccinated animals. Found inside – Page 1272003; 197: 1405–1416. cinated mice acquired sterilizing immunity and the remaining four mice had 20–200 lung CFU 25 days postinfection. Found inside – Page 103Such animals possess a " sterilizing immunity . " Arresting immunity is classified as natural and acquired . Natural arresting immunity is seen in susceptible species in the majority of members of certain breeds which are considered as refractory ... Found inside – Page 230Immunologists now point to a phenomenon that, just a few years ago, seemed implausible: the immune system does have ... Therefore, even a vaccine that fails to deliver sterilizing immunity should still be able to delay or prevent disease. Found inside – Page 2068cell-mediated immunity (CD4 and CD8) and mucosal antibody (IgG and IgA) ... However, no vaccine has been able to elicit “sterilizing immunity,” which ... Immune cells function in an interacting hierarchy that coordinates activities of various cell types according to genetic and environmental contexts. Chlamydia trachomatis infection is the most common bacterial sexually transmitted disease in the United States. This publication contains a number of papers which consider the public health role of vaccines in improving the health of the world's populations, and looks at the challenges of using immunisation to combat emerging and re-emerging diseases ... Found inside – Page 144This is called sterilizing immunity. The unrealistic assumption in this model is that individuals who do not get sterilizing immunity get no effect at ... Found inside – Page 15105Stress or immune suppression of inapparent carriers evasion are believed to present major obstacles to effective vaccine ... horses achieved an apparent Finally , these findings reveal that relatively minor Env variation can " sterilizing immunity ... Found inside – Page 117... down from complete protection provided by sterilizing immunity to delay of disease ... correlates of protection, escape from vaccine-induced immunity, ... Found inside – Page 1487Killed vaccines have been shown to induce sterilizing immunity in avirulent primate models . Thus , protection against homologous HIV - 1 infection has been achieved by immunization of chimpanzees with either whole inactivated HIV - 1 or ... Found inside – Page 12... terminal assessment of virus replication , provirus burden , and antiviral immune responses to define 5 post - challenge categories of immunity reflecting degrees of resistance to SIV infection as follows : ( 1 ) No infection / sterilizing immunity ... Over the course of an effective immune response to an infection, two distinct B cell populations are generated to provide protection against reinfection, long-lived plasma cells (LLPCs) and memory B cells (MBCs). Found insideThe book is built in thematic sections that allow readers to rapidly navigate around related content. Specific sections focus on basic, applied, and clinical immunology. Found inside – Page 198Adjuvants are required to direct the immune response to a co-administrated antigen. ... however, sterilizing immunity was not observed in this trial [316]. Found inside – Page 56The factors that make it difficult for the immune system to prevent and control ... significant sterilizing immunity against a broad variety of viruses, ... However, NP-based vaccination only affords weak protective immunity compared to HA. This is mostly due to the non-sterilizing immunity induced by NP. Using CD40 ligand (CD40L), a key regulator of the immune system, as both a targeting ... In this bold, fascinating book, Biss investigates the metaphors and myths surrounding our conception of immunity and its implications for the individual and the social body. Found inside – Page 43( 19 ) A distinction may be made between two varieties of acquired immunity . 1 . A post - infective immunity , following the acute infection and continuing for a long time after the clinical and microbiological cure . This is a true sterilizing immunity ... The Institute of Medicine, in collaboration with the National Research Council, conducted an in-depth analysis of the scientific necessity for chimpanzees in NIH-funded biomedical and behavioral research. Found insideThe book's main concepts are framed by recent observations on general virus diversity derived from metagenomic studies and current views on the origin and role of viruses in the evolution of the biosphere. Found inside – Page 31Immune Response to Infection and Vaccination Maria M. Mota, Ana Rodriguez ... to be important for sterilizing immunity in response to RAS immunization RTS,S ... Found inside – Page 367This response can be to tolerate the microorganism or to resist it such that at best sterilizing immunity occurs. The immune system is traditionally split ... Found inside – Page 2In helminthiasis, it corresponds to 'concomitant immunity', which protects the host against reinfection but is inactive against established worms from primary or previous exposures (e.g. schistosomiasis). 3. Sterilizing immunity This is very rare in ... Found inside – Page 134Logistical reasons also led to sterilizing immunity's emergence as the " endpoint ” in vaccine trials . HIV infection , untreated , takes an average of 10 ... Found inside – Page 172In particular, when mice were immunized intranasally with H. felis lysate and a combination of CT and immunostimulatory CpGs, sterilizing immunity to H. Found inside – Page 144immunity in the pre-vaccine era. ... The absence of sterilizing immunity makes it possible for natural selection to probe vaccine-induced immunity for ... Found inside – Page 164Other vaccines that produce sterilizing immunity do so by producing a strong neutralizing antibody response.46 Research from this perspective has focused on ... Found insideIf your dog's titer levels indicate that an adequate immune memory has been ... Properly immunized animals have sterilizing immunity that not only prevents ... The aim of the work presented in this thesis was to correlate HIV-specific T cell immunity in EUs with protection from HIV infection. Live, attenuated Plasmodium vaccines against liver stage infection have shown great promise in the mouse model and are being optimized in preliminary human clinical trials. From two of the world’s top scientists and one of the world’s top science writers (all parents), Dirt Is Good is a q&a-based guide to everything you need to know about kids & germs. “Is it OK for my child to eat dirt?” That’s just ... This book provides researchers with a better understanding of what is currently known about these diseases, including whether there is a vaccine available or under development. Marek’s disease is a form of cancer of poultry caused by an important herpesvirus (MDV). It continues to be a threat to poultry health and welfare and worldwide losses are estimated to be US$ 1 billion annually. The untold story of how America's Progressive-era war on smallpox sparked one of the great civil liberties battles of the twentieth century. Found inside – Page 2However the differences between both infections are striking, there is sterilizing immunity in listeriosis; in tuberculosis, we find latency and persistent ... Found insideThis volume presents a collection of reviews derived from work presented at the Aegean Conference: “5th Crossroads Between Innate and Adaptive Immunity”. Found inside – Page 184chemokines and neutralizing antibody titers correlate with sterilizing immunity generated in HIV - 1 vaccinated macaques . Proc Natl Acad Sci USA 1998 ; 95 : 10803–10808 . 323. Wang Y , Tao L , Mitchell E , et al . The effect of immunization ... Found inside – Page 168showed that sterilizing immunity to P. knowlesi can operate without either variant-specific antibodies homologous to the challenge inoculum or opsonizing ... Marek's disease (MD) is a highly transmissible lymphoproliferative disease of chickens caused by an alphaherpesvirus, Marek's disease virus-1 (MDV-1). It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes. Found insideA better option would be vaccines that achieve sterilizing immunity. An alternative would be vaccineinduced prevention of stable infection with M. The slow kinetics of HIV viral growth may be one factor that limits the level of antigen presentation and subsequent CTL response. This book should be helpful for virologists, epidemiologists and HIV researchers. Found inside – Page 11During the first 2-3 days post - infection , the innate immune system controls infection followed by T - celldependent clearance and finally , within two weeks sterilizing immunity is reached ( Cousens and Wing , 2000 ) . If the infection is unable ... Found inside – Page 176As Ehrlich has pointed out , it is necessary to distinguish between sterilizing and non - sterilizing immunity . In bacterial infections as a rule recovery is associated with complete disappearance of the organisms , but bacteria virulent for other ... Nonreception of the great civil liberties battles of what is sterilizing immunity work presented in this thesis was to correlate HIV-specific T immunity. Epidemiologists and HIV researchers applied, and clinical immunology it contains animations videos! Et al to elicit “sterilizing immunity, ” which the aim of the animal tissue the! Usa 1998 ; 95: 10803–10808, Tao L, Mitchell E, al... 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